(Lappaconitine) is a diterpenoid alkaloid isolated from Ranunculaceae plant Lappaconitine, and its chemical name is (1α,14α,16β)-20-B 1,14,16-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate hydrobromide monohydrate. It is the first new non-addictive analgesic drug in China. It has the effects of analgesia, antipyretic, detumescence and local anesthesia, etc., and has no addictive and accumulative effects. Its analgesic effect is stronger than that of indomethacin and weaker than that of morphine. It also has many health benefits, such as anti-inflammatory, anti-tumor, and anti-arrhythmic effects.

 

kintai's leading product, Rapagouline Hydrobromide, is a manufacturer and supplier of Lapagouline Hydrobromide, and has obtained a technical invention patent. Southeast Asia, Russia and more than ten countries, and widely used in medicine, health food, cosmetics, food and beverage, animal feed and other fields.

 

 

 

Aconitum sinomontanum Nakai is a plant of Aconitum in Ranunculaceae. Perennial herb, the root is 20 cm long, cylindrical, and 2 cm thick.It is distributed in Xinjiang, Sichuan, Guizhou, western Hubei, eastern Qinghai, southern Gansu, Shaanxi, Shanxi and Hebei. Growing in hillside grassland or forest.

The root is used for medicine to treat palpitations, stomachache, bruises, etc.a

 

 

 

 

All of Kintai's Aconitum sinomontanum Nakai roots grow on the alpine grasslands of Xinjiang above 2500 meters above sea level, pollution-free, green and organic. Every year, we purchase about 200 tons of Aconitum sinomontanum Nakai roots from Xinjiang, and produce more than 800 kg of lappaconitine  with a content of more than 96%.

 

 

 

Kintai mainly produces high-grade homogenin hydrobromide 98% (this product), if you need other specifications, please feel free to contact us.

 

 

 

Molecular formula:	C32H45BrN2O8	Molecular weight:	665.61
Mol file:	97792-45-5.mol	Melting point:	223-226 º C
Storage conditions:	2-8 ° C

 

 

Product name	Lappaconitine
Extract source	Aconitum sinomontanum Nakai
Extraction Solvent	Water/Ethyl alcohol
Appearance	White Powder
Solubility	Dissolved in water
Identification	Titration;HPLC
Sulphated Ash	NMT 0.5%
Heavy metals	NMT 20 PPM
Loss On Drying	NMT 5.0%
Powder size	80Mesh, NLT90%
Assay of Kava Root Extract (HPLC test, percent, Standard in House)	Min. 98.0%
Microbiological Quality (Total viable aerobic count)
- Bacteria, CFU/g, not more than	NMT 103
- Moulds and yeasts, CFU/g, not more than	NMT 102
- E.coli, Salmonella, S. aureus, CFU/g	Absence
Storage	2-8 ℃
Shelf life	three years

 

 

 

Health Benefits

According to the latest pharmacological experiments, Lappaconitine hydrobromide has the following effects on health:

Analgesic effect, without obvious toxicity and addiction;

Anti inflammatory effect, lappaconitine  has anti acute and chronic inflammatory effects;

Anti arrhythmic effect, lappaconitine  can significantly improve myocardial ischemic arrhythmia, thereby reducing the incidence of arrhythmia;

Cooling and eliminating fever: It has a significant antipyretic effect on various types of fever. It has been clinically proven that the antipyretic effect is better than hydropyrine, and its cooling effect is equal to aspirin and other western medicines.

 

 

Application

It is applicable to gastrointestinal ulcer, gastritis, hepatitis, cholecystitis, rheumatism, sciatica, toothache, postoperative pain, cancer pain, etc.

 

The hydrobromide is commonly used in clinical practice, and there are various preparations and specifications. Their administration methods, routes, absorption speed, and stability are different, and each has its own characteristics. The preparations of different manufacturers may have different drug effects and adverse reactions due to different production processes. How to choose please consult your doctor.
1) Houginine hydrobromide tablets: 5 mg; 10 mg.
2) Hovenine hydrobromide for injection: 4 mg; 8 mg.
3) Urine hydrobromide injection: 4mg/2ml; 8mg/2ml.
4) Urumine hydrobromide glucose injection: 250 ml (4 mg urine hydrobromide, 12.5 grams of 5) glucose); 500 ml (8 mg urine hydrobromide, 25 grams of glucose)
6) Gao Ujiasu patch: 12 mg.

 

 

 

(1) The analgesic effect of lappaconitine is lasting, because the anesthetic isomer of aconitum has strong anesthetic effect from deep layer to shallow layer.

(2) It is clinically proved that the local anesthetic effect is equivalent to cocaine; The effect of nerve conduction block is 5.25 times that of cocaine and 13 times that of procaine; The effect of infiltration anesthesia is far stronger than that of procaine and cocaine.

(3) The lappaconitine has high safety, no addiction, mutagenic and carcinogenic effects, no accumulation, stimulation, allergic reaction and toxic effects on the immune system. The clinical application proved that there was no case of poisoning within the prescribed usage and dosage.

(4) It has significant antipyretic effect on all kinds of fever. It is clinically proved that antipyretic effect is better than aminopyrine, and its cooling effect is equal to aspirin and other western medicines.

 

 

 

 

 

 

If you want to purchase high quality Lappaconitine hydrobromide, please feel free to contact us at or feedback in next page.

 

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